Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

A local regulatory T cell feedback circuit maintains immune homeostasis by pruning self-activated T cells.

Wong, Harikesh S; Park, Kyemyung; Gola, Anita; Baptista, Antonio P; Miller, Christine H; Deep, Deeksha; Lou, Meng; Boyd, Lisa F; Rudensky, Alexander Y; Savage, Peter A; Altan-Bonnet, Grégoire; Tsang, John S; Germain, Ronald N.

Cell ; 184(15): 3981-3997.e22, 2021 07 22.

Artigo em Inglês | MEDLINE | ID: mdl-34157301

2.

Adaptive immune responses to SARS-CoV-2 persist in the pharyngeal lymphoid tissue of children.

Xu, Qin; Milanez-Almeida, Pedro; Martins, Andrew J; Radtke, Andrea J; Hoehn, Kenneth B; Oguz, Cihan; Chen, Jinguo; Liu, Can; Tang, Juanjie; Grubbs, Gabrielle; Stein, Sydney; Ramelli, Sabrina; Kabat, Juraj; Behzadpour, Hengameh; Karkanitsa, Maria; Spathies, Jacquelyn; Kalish, Heather; Kardava, Lela; Kirby, Martha; Cheung, Foo; Preite, Silvia; Duncker, Patrick C; Kitakule, Moses M; Romero, Nahir; Preciado, Diego; Gitman, Lyuba; Koroleva, Galina; Smith, Grace; Shaffer, Arthur; McBain, Ian T; McGuire, Peter J; Pittaluga, Stefania; Germain, Ronald N; Apps, Richard; Schwartz, Daniella M; Sadtler, Kaitlyn; Moir, Susan; Chertow, Daniel S; Kleinstein, Steven H; Khurana, Surender; Tsang, John S; Mudd, Pamela; Schwartzberg, Pamela L; Manthiram, Kalpana.

Nat Immunol ; 24(1): 186-199, 2023 01.

Artigo em Inglês | MEDLINE | ID: mdl-36536106

3.

Resident Macrophages Cloak Tissue Microlesions to Prevent Neutrophil-Driven Inflammatory Damage.

Uderhardt, Stefan; Martins, Andrew J; Tsang, John S; Lämmermann, Tim; Germain, Ronald N.

Cell ; 177(3): 541-555.e17, 2019 04 18.

Artigo em Inglês | MEDLINE | ID: mdl-30955887

4.

Systems biology in immunology: a computational modeling perspective.

Germain, Ronald N; Meier-Schellersheim, Martin; Nita-Lazar, Aleksandra; Fraser, Iain D C.

Annu Rev Immunol ; 29: 527-85, 2011.

Artigo em Inglês | MEDLINE | ID: mdl-21219182

5.

Quantifying in situ adaptive immune cell cognate interactions in humans.

Liarski, Vladimir M; Sibley, Adam; van Panhuys, Nicholas; Ai, Junting; Chang, Anthony; Kennedy, Domenick; Merolle, Maria; Germain, Ronald N; Giger, Maryellen L; Clark, Marcus R.

Nat Immunol ; 20(4): 503-513, 2019 04.

Artigo em Inglês | MEDLINE | ID: mdl-30778242

6.

Hyperactivated PI3KÎ´ promotes self and commensal reactivity at the expense of optimal humoral immunity.

Preite, Silvia; Cannons, Jennifer L; Radtke, Andrea J; Vujkovic-Cvijin, Ivan; Gomez-Rodriguez, Julio; Volpi, Stefano; Huang, Bonnie; Cheng, Jun; Collins, Nicholas; Reilley, Julie; Handon, Robin; Dobbs, Kerry; Huq, Lutfi; Raman, Indu; Zhu, Chengsong; Li, Quan-Zhen; Li, Ming O; Pittaluga, Stefania; Uzel, Gulbu; Notarangelo, Luigi D; Belkaid, Yasmine; Germain, Ronald N; Schwartzberg, Pamela L.

Nat Immunol ; 19(9): 986-1000, 2018 09.

Artigo em Inglês | MEDLINE | ID: mdl-30127432

7.

Healing the NIH-Funded Biomedical Research Enterprise.

Germain, Ronald N.

Cell ; 161(7): 1485-91, 2015 Jun 18.

Artigo em Inglês | MEDLINE | ID: mdl-26091028

8.

Microbiota-Dependent Sequelae of Acute Infection Compromise Tissue-Specific Immunity.

Fonseca, Denise Morais da; Hand, Timothy W; Han, Seong-Ji; Gerner, Michael Y; Glatman Zaretsky, Arielle; Byrd, Allyson L; Harrison, Oliver J; Ortiz, Alexandra M; Quinones, Mariam; Trinchieri, Giorgio; Brenchley, Jason M; Brodsky, Igor E; Germain, Ronald N; Randolph, Gwendalyn J; Belkaid, Yasmine.

Cell ; 163(2): 354-66, 2015 Oct 08.

Artigo em Inglês | MEDLINE | ID: mdl-26451485

9.

Niche-Specific Reprogramming of Epigenetic Landscapes Drives Myeloid Cell Diversity in Nonalcoholic Steatohepatitis.

Seidman, Jason S; Troutman, Ty D; Sakai, Mashito; Gola, Anita; Spann, Nathanael J; Bennett, Hunter; Bruni, Cassi M; Ouyang, Zhengyu; Li, Rick Z; Sun, Xiaoli; Vu, BaoChau T; Pasillas, Martina P; Ego, Kaori M; Gosselin, David; Link, Verena M; Chong, Ling-Wa; Evans, Ronald M; Thompson, Bonne M; McDonald, Jeffrey G; Hosseini, Mojgan; Witztum, Joseph L; Germain, Ronald N; Glass, Christopher K.

Immunity ; 52(6): 1057-1074.e7, 2020 06 16.

Artigo em Inglês | MEDLINE | ID: mdl-32362324

10.

Focusing in on T cell cross-reactivity.

Mandl, Judith N; Germain, Ronald N.

Cell ; 157(5): 1006-8, 2014 May 22.

Artigo em Inglês | MEDLINE | ID: mdl-24855938

11.

Global analyses of human immune variation reveal baseline predictors of postvaccination responses.

Tsang, John S; Schwartzberg, Pamela L; Kotliarov, Yuri; Biancotto, Angelique; Xie, Zhi; Germain, Ronald N; Wang, Ena; Olnes, Matthew J; Narayanan, Manikandan; Golding, Hana; Moir, Susan; Dickler, Howard B; Perl, Shira; Cheung, Foo.

Cell ; 157(2): 499-513, 2014 Apr 10.

Artigo em Inglês | MEDLINE | ID: mdl-24725414

12.

The ß₁-adrenergic receptor links sympathetic nerves to T cell exhaustion.

Globig, Anna-Maria; Zhao, Steven; Roginsky, Jessica; Maltez, Vivien I; Guiza, Juan; Avina-Ochoa, Natalia; Heeg, Maximilian; Araujo Hoffmann, Filipe; Chaudhary, Omkar; Wang, Jiawei; Senturk, Gokhan; Chen, Dan; O'Connor, Carolyn; Pfaff, Samuel; Germain, Ronald N; Schalper, Kurt A; Emu, Brinda; Kaech, Susan M.

Nature ; 622(7982): 383-392, 2023 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-37731001

13.

The Chemoattractant Receptor Ebi2 Drives Intranodal Naive CD4⁺ T Cell Peripheralization to Promote Effective Adaptive Immunity.

Baptista, Antonio P; Gola, Anita; Huang, Yuefeng; Milanez-Almeida, Pedro; Torabi-Parizi, Parizad; Urban, Joseph F; Shapiro, Virginia S; Gerner, Michael Y; Germain, Ronald N.

Immunity ; 50(5): 1188-1201.e6, 2019 05 21.

Artigo em Inglês | MEDLINE | ID: mdl-31053504

14.

A systems analysis identifies a feedforward inflammatory circuit leading to lethal influenza infection.

Brandes, Marlène; Klauschen, Frederick; Kuchen, Stefan; Germain, Ronald N.

Cell ; 154(1): 197-212, 2013 Jul 03.

Artigo em Inglês | MEDLINE | ID: mdl-23827683

15.

The adaptor MAVS promotes NLRP3 mitochondrial localization and inflammasome activation.

Subramanian, Naeha; Natarajan, Kannan; Clatworthy, Menna R; Wang, Ze; Germain, Ronald N.

Cell ; 153(2): 348-61, 2013 Apr 11.

Artigo em Inglês | MEDLINE | ID: mdl-23582325

16.

Spatiotemporal basis of innate and adaptive immunity in secondary lymphoid tissue.

Qi, Hai; Kastenmüller, Wolfgang; Germain, Ronald N.

Annu Rev Cell Dev Biol ; 30: 141-67, 2014.

Artigo em Inglês | MEDLINE | ID: mdl-25150013

17.

A spatially-organized multicellular innate immune response in lymph nodes limits systemic pathogen spread.

Kastenmüller, Wolfgang; Torabi-Parizi, Parizad; Subramanian, Naeha; Lämmermann, Tim; Germain, Ronald N.

Cell ; 150(6): 1235-48, 2012 Sep 14.

Artigo em Inglês | MEDLINE | ID: mdl-22980983

18.

Author Correction: Commensal-driven immune zonation of the liver promotes host defence.

Gola, Anita; Dorrington, Michael G; Speranza, Emily; Sala, Claudia; Shih, Rochelle M; Radtke, Andrea J; Wong, Harikesh S; Baptista, Antonio P; Hernandez, Jonathan M; Castellani, Gastone; Fraser, Iain D C; Germain, Ronald N.

Nature ; 597(7874): E1, 2021 Sep.

Artigo em Inglês | MEDLINE | ID: mdl-34373651

19.

Commensal-driven immune zonation of the liver promotes host defence.

Gola, Anita; Dorrington, Michael G; Speranza, Emily; Sala, Claudia; Shih, Rochelle M; Radtke, Andrea J; Wong, Harikesh S; Baptista, Antonio P; Hernandez, Jonathan M; Castellani, Gastone; Fraser, Iain D C; Germain, Ronald N.

Nature ; 589(7840): 131-136, 2021 01.

Artigo em Inglês | MEDLINE | ID: mdl-33239787

20.

Organ Mapping Antibody Panels: a community resource for standardized multiplexed tissue imaging.

Quardokus, Ellen M; Saunders, Diane C; McDonough, Elizabeth; Hickey, John W; Werlein, Christopher; Surrette, Christine; Rajbhandari, Presha; Casals, Anna Martinez; Tian, Hua; Lowery, Lisa; Neumann, Elizabeth K; Björklund, Frida; Neelakantan, Taruna V; Croteau, Josh; Wiblin, Anne E; Fisher, Jeremy; Livengood, April J; Dowell, Karen G; Silverstein, Jonathan C; Spraggins, Jeffrey M; Pryhuber, Gloria S; Deutsch, Gail; Ginty, Fiona; Nolan, Garry P; Melov, Simon; Jonigk, Danny; Caldwell, Michael A; Vlachos, Ioannis S; Muller, Werner; Gehlenborg, Nils; Stockwell, Brent R; Lundberg, Emma; Snyder, Michael P; Germain, Ronald N; Camarillo, Jeannie M; Kelleher, Neil L; Börner, Katy; Radtke, Andrea J.

Nat Methods ; 20(8): 1174-1178, 2023 08.

Artigo em Inglês | MEDLINE | ID: mdl-37468619

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